The present investigation is a trial made to formulate sustained release matrix tablets of Ambroxol hydrochloride and study the effect of natural hydrophilic polymers like gum karaya, guar gum on in vitro release performance alone and in combination with guar gum using different drug: polymer ratios, by wet granulation technique. The prepared granules were evaluated for angle of repose, bulk density, compressibility index, Hauser ratio and drug content. All the lubricated formulations were compressed using 7mm flat faced punches. The prepared tablets were evaluated for physical characteristics like thickness, weight variation test, drug content, hardness, friability and in vitro release kinetics and swelling index. The granules showed satisfactory flow properties, compressibility and drug content. All the tablet formulations showed acceptable pharmaco technical properties. In vitro release studies show that gum karaya alone unable to protect drug from immediate release. Hence trials made with combination of guar gum , these gums get hydrated, swells and form a thick gel structure which prevents the immediate release of the drug. The optimized Ambroxol hydrochloride matrix tablets F6 (1:2) were subjected to short term stability studies at 45°C with 75% RH for 45 days revealed that no significant differences in physical appearance, drug content, dissolution, T50, and T90 were found.
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